Journal of Pathology and Translational Medicine

Original Articles

Clinicopathologic characterization of cervical metastasis from an unknown primary tumor: a multicenter study in Korea: Miseon Lee, Uiree Jo, Joon Seon Song, Youn Soo Lee, Chang Gok Woo, Dong-Hoon Kim, Jung Yeon Kim, Sun Och Yoon, Kyung-Ja Cho; J Pathol Transl Med. 2023;57(3):166-177. Published online May 10, 2023; DOI: https://doi.org/10.4132/jptm.2023.04.12

1,407 View
100 Download
1 Web of Science
1 Crossref

Background
Research regarding cervical metastasis from an unknown primary tumor (CUP) according to human papillomavirus (HPV) and Epstein-Barr virus (EBV) status in Korea has been sporadic and small-scale. This study aims to analyze and understand the characteristics of CUP in Korea according to viral and p16 and p53 status through a multicenter study.
Methods
Ninety-five cases of CUP retrieved from six hospitals in Korea between January 2006 and December 2016 were subjected to high-risk HPV detection (DNA in situ hybridization [ISH] or real-time polymerase chain reaction), EBV detection (ISH), and immunohistochemistry for p16 and p53.
Results
CUP was HPV-related in 37 cases (38.9%), EBV-related in five cases (5.3%), and unrelated to HPV or EBV in 46 cases (48.4%). HPV-related CUP cases had the best overall survival (OS) (p = .004). According to the multivariate analysis, virus-unrelated disease (p = .023) and longer smoking duration (p < .005) were prognostic factors for poor OS. Cystic change (p = .016) and basaloid pattern (p < .001) were more frequent in HPV-related cases, and lymphoepithelial lesion was frequent in EBV-related cases (p = .010). There was no significant association between viral status and p53 positivity (p = .341), smoking status (p = .728), or smoking duration (p = .187). Korean data differ from Western data in the absence of an association among HPV, p53 positivity, and smoking history.
Conclusions
Virus-unrelated CUP in Korea had the highest frequency among all CUP cases. HPV-related CUP is similar to HPV-mediated oropharyngeal cancer and EBVrelated CUP is similar to nasopharyngeal cancer in terms of characteristics, respectively.

Citations

Citations to this article as recorded by

Expansion of tumor-infiltrating lymphocytes from head and neck squamous cell carcinoma to assess the potential of adoptive cell therapy
Sangjoon Choi, Mofazzal Hossain, Hyun Lee, Jina Baek, Hye Seon Park, Chae-Lyul Lim, DoYeon Han, Taehyun Park, Jong Hyeok Kim, Gyungyub Gong, Mi-Na Kweon, Hee Jin Lee
Cancer Immunology, Immunotherapy.2024;[Epub] CrossRef

Frequent apocrine changes in pleomorphic adenoma with malignant transformation: a possible pre-malignant step in ductal carcinoma ex pleomorphic adenoma: Joon Seon Song, Yeseul Kim, Yoon-Se Lee, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Kyung-Ja Cho; J Pathol Transl Med. 2023;57(3):158-165. Published online May 10, 2023; DOI: https://doi.org/10.4132/jptm.2023.03.13

1,419 View
94 Download
1 Crossref

Abstract PDF

Background
The most common type of carcinoma ex pleomorphic adenoma (CPA) is histologically equivalent to salivary duct carcinoma, which has an apocrine phenotype. Invasive CPA is often accompanied by non-invasive or in situ carcinoma, an observation that suggests the presence of precursor lesions. The aim of this study was to identify candidate precursor lesions of CPA within pleomorphic adenoma (PA).
Methods
Eleven resected cases of CPA with residual PA and 17 cases of PA with atypical changes were subjected to immunohistochemistry (IHC) for p53, human epidermal growth factor receptor 2 (HER2), androgen receptor (AR), pleomorphic adenoma gene 1, gross cystic disease fluid protein-15 (GCDFP-15), and anti-mitochondrial antibody.
Results
Invasive or in situ carcinoma cells in all CPAs were positive for AR, GCDFP-15, and HER2. Atypical foci in PAs corresponded to either apocrine or oncocytic changes on the basis of their reactivity to AR, GCDFP-15, and anti-mitochondrial antibody. Atypical cells in PAs surrounding CPAs had an apocrine phenotype without HER2 expression.
Conclusions
Our study identified frequent apocrine changes in residual PAs in CPA cases, suggesting a possible precursor role of apocrine changes. We recommend the use of HER2 IHC in atypical PAs, and that clinicians take HER2 positivity into serious consideration.

Citations

Citations to this article as recorded by

Characterization of a Molecularly Distinct Subset of Oncocytic Pleomorphic Adenomas/Myoepitheliomas Harboring Recurrent ZBTB47-AS1::PLAG1 Gene Fusion
Ziyad Alsugair, Jimmy Perrot, Françoise Descotes, Jonathan Lopez, Anne Champagnac, Daniel Pissaloux, Claire Castain, Mihaela Onea, Philippe Céruse, Pierre Philouze, Charles Lépine, Marie-Delphine Lanic, Marick Laé, Valérie Costes-Martineau, Nazim Benzerdj
American Journal of Surgical Pathology.2024; 48(5): 551. CrossRef

Case Study

Hepatoid thymic carcinoma: a case report of a rare subtype of thymic carcinoma: Ji-Seon Jeong, Hyo Jeong Kang, Uiree Jo, Min Jeong Song, Soon Yeol Nam, Joon Seon Song; J Pathol Transl Med. 2021;55(3):230-234. Published online April 14, 2021; DOI: https://doi.org/10.4132/jptm.2021.03.10

2,848 View
105 Download
3 Web of Science
1 Crossref

Abstract PDF

Hepatoid thymic carcinoma is an extremely rare subtype of primary thymus tumor resembling “pure” hepatoid adenocarcinomas with hepatocyte paraffin 1 (Hep-Par-1) expression. A 53-year-old man presented with voice change and a neck mass. Multiple masses involving the thyroid, cervical and mediastinal lymph nodes, and lung were detected on computed tomography. Papillary thyroid carcinoma was confirmed by biopsy, and the patient underwent neoadjuvant chemoradiation therapy. However, the anterior mediastinal mass was enlarged after the treatment whereas the multiple masses in the thyroid and neck decreased in size. Microscopically, polygonal tumor cells formed solid sheets or trabeculae resembling hepatocytes and infiltrated remnant thymus. The tumor cells showed immunopositivity for cytokeratin 7, cytokeratin 19, and Hep-Par-1 and negativity for α-fetoprotein. Possibilities of germ cell tumor, squamous cell carcinoma, and metastasis of thyroid papillary carcinoma were excluded by immunohistochemistry. This report on the new subtype of thymic carcinoma is the third in English literature thus far.

Citations

Citations to this article as recorded by

Hepatoid tumors of the gastrointestinal/pancreatobiliary district: morphology, immunohistochemistry, and molecular profiles
Paola Mattiolo, Aldo Scarpa, Claudio Luchini
Human Pathology.2023; 132: 169. CrossRef

Original Articles

Primary squamous cell carcinoma of the salivary gland: immunohistochemical analysis and comparison with metastatic squamous cell carcinoma: Uiree Jo, Joon Seon Song, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Kyung-Ja Cho; J Pathol Transl Med. 2020;54(6):489-496. Published online August 31, 2020; DOI: https://doi.org/10.4132/jptm.2020.07.19

5,209 View
156 Download
11 Web of Science
13 Crossref

Abstract PDF Supplementary Material

Background
Primary squamous cell carcinoma (SCC) of the salivary gland is a rare disease, and distinguishing primary SCC from metastatic SCC is difficult. This study investigated the histological and immunohistochemical differences between primary and metastatic salivary gland SCC to improve the accuracy of diagnosis and to explore the pathogenesis of this disease.
Methods
Data of 16 patients who underwent surgery for SCC of salivary glands between 2000 and 2018 at Asan Medical Center were retrieved. Eight patients had a history of SCC at other sites, and eight patients had only salivary gland SCC. Immunostaining for p16, p53, androgen receptor (AR), gross cystic disease fluid protein 15 (GCDFP-15), and c-erbB2, as well as mucicarmine staining, were compared between the two groups.
Results
Most tumors were located in the center of the salivary glands with extraparenchymal extension. The histology of primary SCC of the salivary gland was consistent with moderately differentiated SCC with extensive desmoplastic reaction and peritumoral inflammation. Involvement of the salivary gland ducts and transition into the ductal epithelium were observed in two cases. Metastatic SCC resembled the primary tumor histologically and was associated with central necrosis. Both groups exhibited negative mucin staining. Two, one, and one primary SCC case exhibited AR, GCDFP-15, and c-erbB2 positivity, respectively.
Conclusions
A subset of primary SCCs originated in salivary ducts or was related to salivary duct carcinoma. Distinguishing primary from metastatic SCC of the salivary gland is difficult using histologic features and immunoprofiles. A comprehensive review of the medical history is essential.

Citations

Citations to this article as recorded by

Primary salivary gland squamous cell carcinoma with sialolithiasis in the submandibular gland: A case report and literature review
Sawako Ono, Katsutoshi Hirose, Yuji Hirata, Marie Yamada, Satoko Nakamura, Hidetaka Yamamoto
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2024;[Epub] CrossRef
A case of primary squamous cell carcinoma of the parotid gland and review of the literature
Jingli Zhao, Xinrong Nan, Chuhuan Zhou, Nan Jiang, Liangliang Tian
Journal of Case Reports and Images in Oncology.2024; 10(1): 7. CrossRef
Metastatic cutaneous squamous cell carcinoma accounts for nearly all squamous cell carcinomas of the parotid gland
Patrick J. Bradley, Göran Stenman, Lester D. R. Thompson, Alena Skálová, Roderick H. W. Simpson, Pieter J. Slootweg, Alessandro Franchi, Nina Zidar, Alfons Nadal, Henrik Hellquist, Michelle D. Williams, Ilmo Leivo, Abbas Agaimy, Alfio Ferlito
Virchows Archiv.2024;[Epub] CrossRef
Salivary gland fine needle aspiration: a focus on diagnostic challenges and tips for achieving an accurate diagnosis
Carla Saoud, Hansen Lam, Sandra I. Sanchez, Zahra Maleki
Diagnostic Histopathology.2023; 29(8): 357. CrossRef
Salivary gland pathologies: evolution in classification and association with unique genetic alterations
Michał Żurek, Łukasz Fus, Kazimierz Niemczyk, Anna Rzepakowska
European Archives of Oto-Rhino-Laryngology.2023; 280(11): 4739. CrossRef
A retrospective study of nonneoplastic and neoplastic disorders of the salivary glands
Sorin Vamesu, Oana Andreea Ursica, Ana Maria Gurita, Raluca Ioana Voda, Mariana Deacu, Mariana Aschie, Madalina Bosoteanu, Georgeta Camelia Cozaru, Anca Florentina Mitroi, Cristian Ionut Orasanu
Medicine.2023; 102(42): e35751. CrossRef
Pembrolizumab as a first line therapy in a patient with extensive mucoepidermoid salivary gland carcinoma. A complete clinical, radiological and pathological response. A very specific case
Raed Farhat, Noam Asna, Yaniv Avraham, Ashraf Khater, Majd Asakla, Alaa Safia, Sergio Szvalb, Nidal Elkhatib, Shlomo Merchavy
Discover Oncology.2022;[Epub] CrossRef
Morphologic CT and MRI features of primary parotid squamous cell carcinoma and its predictive factors for differential diagnosis with mucoepidermoid carcinoma
Xiaohua Ban, Huijun Hu, Yue Li, Lingjie Yang, Yu Wang, Rong Zhang, Chuanmiao Xie, Cuiping Zhou, Xiaohui Duan
Insights into Imaging.2022;[Epub] CrossRef
A Rare Case of Primary Squamous Cell Carcinoma of the Submandibular Salivary Gland: Brief Overview of Diagnostic Ambiguity and Treatment Challenges
Pawan Hingnikar, Anendd Jadhav, Nitin D Bhola
Cureus.2022;[Epub] CrossRef
Necrotizing Sialometaplasia of the Hard Palate: Diagnosis and Treatment
Sangeun Lee, Yun Sung Lim, Kyuho Lee, Bo Hae Kim
Journal of Clinical Otolaryngology Head and Neck Surgery.2022; 33(4): 236. CrossRef
Parotid Salivary Duct Carcinoma With a Prominent Squamous Component: Immunohistochemical Profile, Diagnostic Pitfalls, and Therapeutic Implications
Naomi Hardy, Joshua Thompson, Ranee Mehra, Cinthia B. Drachenberg, Kyle Hatten, John C. Papadimitriou
International Journal of Surgical Pathology.2021; 29(7): 726. CrossRef
Intrasalivary Thymic Carcinoma: A Case Report and Literature Review
Michał Kunc, Alexandra Kamieniecki, Grzegorz Walczak, Tomasz Nowicki, Bartosz Wasąg, Bogusław Mikaszewski, Dominik Stodulski, Wojciech Biernat
Head and Neck Pathology.2021; 16(3): 857. CrossRef
Cancer Stem Cell Markers in Squamous Cell Carcinomas of the Salivary Glands
Mattis Bertlich, Julia Kitz, Marie Kruizenga, Jennifer Lee Spiegel, Martin Canis, Friedrich Ihler, Frank Haubner, Bernhard G. Weiss, Mark Jakob
Oncology.2021; 99(6): 402. CrossRef

Sarcoma metastasis to the pancreas: experience at a single institution: Miseon Lee, Joon Seon Song, Seung-Mo Hong, Se Jin Jang, Jihun Kim, Ki Byung Song, Jae Hoon Lee, Kyung-Ja Cho; J Pathol Transl Med. 2020;54(3):220-227. Published online April 22, 2020; DOI: https://doi.org/10.4132/jptm.2020.03.04

5,448 View
148 Download
7 Web of Science
7 Crossref

Abstract PDF

Background
Reports of metastatic sarcoma to the pancreas are limited. We reviewed the clinicopathologic characteristics of such cases.
Methods
We reviewed 124 cases of metastatic tumors to the pancreas diagnosed at Asan Medical Center between 2000 and 2017.
Results
Metastatic tumors to the pancreas consisted of 111 carcinomas (89.5%), 12 sarcomas (9.6%), and one melanoma (0.8%). Primary sarcoma sites were bone (n = 4); brain, lung, and soft tissue (n = 2 for each); and the uterus and pulmonary vein (n = 1 for each). Pathologically, the 12 sarcomas comprised 2 World Health Organization grade III solitary fibrous tumors/hemangiopericytomas, and one case each of synovial sarcoma, malignant solitary fibrous tumor, undifferentiated pleomorphic sarcoma, osteosarcoma, mesenchymal chondrosarcoma, intimal sarcoma, myxofibrosarcoma, myxoid liposarcoma, rhabdomyosarcoma, subtype uncertain, and high-grade spindle-cell sarcoma of uncertain type. The median interval between primary cancer diagnosis and pancreatic metastasis was 28.5 months. One case manifested as a solitary pancreatic osteosarcoma metastasis 15 months prior to detection of osteosarcoma in the femur and was initially misdiagnosed as sarcomatoid carcinoma of the pancreas.
Conclusions
The metastatic sarcoma should remain a differential diagnosis when spindle-cell malignancy is found in the pancreas, even for solitary lesions or in patients without prior history.

Citations

Citations to this article as recorded by

Metástasis pancreática de sarcoma, un hallazgo infrecuente
Daniel Aparicio-López, Jorge Chóliz-Ezquerro, Carlos Hörndler-Algárate, Mario Serradilla-Martín
Gastroenterología y Hepatología.2023; 46(5): 376. CrossRef
Pancreatic metastasis from sarcoma, an infrequent finding
Daniel Aparicio-López, Jorge Chóliz-Ezquerro, Carlos Hörndler-Algárate, Mario Serradilla-Martín
Gastroenterología y Hepatología (English Edition).2023; 46(5): 376. CrossRef
Acute pancreatitis secondary to osteosarcoma metastasis
Pablo Salmón Olavarría, Ana Gordo Ortega, Maren Eizagirre Ubegun, Verónica Ubieto Capella, Elena Carracedo Vega, Juan Carrascosa Gil, David Ruiz-Clavijo García
Revista Española de Enfermedades Digestivas.2023;[Epub] CrossRef
First Recurrence of Synovial Sarcoma Presenting With Solitary Pancreatic Mass
Raja R Narayan, Greg W Charville, Daniel Delitto, Kristen N Ganjoo
Cureus.2022;[Epub] CrossRef
Intravenous Leiomyosarcoma of the Lower Extremity: As Peripheral as It Gets
Levent F Umur, Selami Cakmak, Mehmet Isyar, Hamdi Tokoz
Cureus.2021;[Epub] CrossRef
Could the burden of pancreatic cancer originate in childhood?
Smaranda Diaconescu, Georgiana Emmanuela Gîlcă-Blanariu, Silvia Poamaneagra, Otilia Marginean, Gabriela Paduraru, Gabriela Stefanescu
World Journal of Gastroenterology.2021; 27(32): 5322. CrossRef
Staged Surgical Resection of Primary Pulmonary Synovial Sarcoma with Synchronous Multiple Pancreatic Metastases: Report of a Rare Case and Review of the Literature
Panagiotis Dorovinis, Nikolaos Machairas, Stylianos Kykalos, Paraskevas Stamopoulos, George Agrogiannis, Nikolaos Nikiteas, Georgios C. Sotiropoulos
Journal of Gastrointestinal Cancer.2021; 52(3): 1151. CrossRef

Comparison of Squamous Cell Carcinoma of the Tongue between Young and Old Patients: Gyuheon Choi, Joon Seon Song, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Jong-Lyel Roh, Bu-Kyu Lee, Kyung-Ja Cho; J Pathol Transl Med. 2019;53(6):369-377. Published online October 11, 2019; DOI: https://doi.org/10.4132/jptm.2019.09.16

5,695 View
177 Download
6 Web of Science
9 Crossref

Abstract PDF Supplementary Material

Background
The worldwide incidence of squamous cell carcinoma of the tongue (SCCOT) in young patients has been increasing. We investigated clinicopathologic features of this unique population and compared them with those of SCCOT in the elderly to delineate its pathogenesis.
Methods
We compared clinicopathological parameters between patients under and over 45 years old. Immunohistochemical assays of estrogen receptor, progesterone receptor, androgen receptor, p53, p16, mdm2, cyclin D1, and glutathione S-transferase P1 were also compared between them.
Results
Among 189 cases, 51 patients (27.0%) were under 45 years of age. A higher proportion of women was seen in the young group, but was not statistically significant. Smoking and drinking behaviors between age groups were similar. Histopathological and immunohistochemical analysis showed no significant difference by age and sex other than higher histologic grades observed in young patients.
Conclusions
SCCOT in young adults has similar clinicopathological features to that in the elderly, suggesting that both progress via similar pathogenetic pathways.

Citations

Citations to this article as recorded by

High Failure Rates in Young Nonsmoker Nondrinkers With Squamous Cell Carcinoma of the Oral Tongue
Brianna M. Jones, Dillan F. Villavisanis, Eric J. Lehrer, Daniel R. Dickstein, Kunal K. Sindhu, Krzysztof J. Misiukiewicz, Marshall Posner, Jerry T. Liu, Vishal Gupta, Sonam Sharma, Scott A. Roof, Marita Teng, Eric M. Genden, Richard L. Bakst
The Laryngoscope.2023; 133(5): 1110. CrossRef
Characteristics of oral squamous cell carcinoma focusing on cases unaffected by smoking and drinking: A multicenter retrospective study
Hiroyuki Harada, Masahiro Kikuchi, Ryo Asato, Kiyomi Hamaguchi, Hisanobu Tamaki, Masanobu Mizuta, Ryusuke Hori, Tsuyoshi Kojima, Keigo Honda, Takashi Tsujimura, Yohei Kumabe, Kazuyuki Ichimaru, Yoshiharu Kitani, Koji Ushiro, Morimasa Kitamura, Shogo Shino
Head & Neck.2023; 45(7): 1812. CrossRef
Genetic characteristics of advanced oral tongue squamous cell carcinoma in young patients
Sehui Kim, Chung Lee, Hyangmi Kim, Sun Och Yoon
Oral Oncology.2023; 144: 106466. CrossRef
Oral Squamous Cell Carcinoma Frequency in Young Patients from Referral Centers Around the World
Rafael Ferreira e Costa, Marina Luiza Baião Leão, Maria Sissa Pereira Sant’Ana, Ricardo Alves Mesquita, Ricardo Santiago Gomez, Alan Roger Santos-Silva, Syed Ali Khurram, Artysha Tailor, Ciska-Mari Schouwstra, Liam Robinson, Willie F. P. van Heerden, Rami
Head and Neck Pathology.2022; 16(3): 755. CrossRef
Early-onset oral cancer as a clinical entity: aetiology and pathogenesis
E.S. Kolegova, M.R. Patysheva, I.V. Larionova, I.K. Fedorova, D.E. Kulbakin, E.L. Choinzonov, E.V. Denisov
International Journal of Oral and Maxillofacial Surgery.2022; 51(12): 1497. CrossRef
The effect of age on the clinicopathological features of oral squamous cell carcinoma
Alaa S Saeed, Bashar H Abdullah
Journal of Baghdad College of Dentistry.2022; 34(1): 25. CrossRef
Survival Outcomes in Oral Tongue Cancer: A Mono-Institutional Experience Focusing on Age
Mohssen Ansarin, Rita De Berardinis, Federica Corso, Gioacchino Giugliano, Roberto Bruschini, Luigi De Benedetto, Stefano Zorzi, Fausto Maffini, Fabio Sovardi, Carolina Pigni, Donatella Scaglione, Daniela Alterio, Maria Cossu Rocca, Susanna Chiocca, Sara
Frontiers in Oncology.2021;[Epub] CrossRef
A meta-analysis of oral squamous cell carcinoma in young adults with a comparison to the older group patients (2014–2019)
Khadijah Mohideen, C Krithika, Nadeem Jeddy, Thayumanavan Balakrishnan, R Bharathi, SLeena Sankari
Contemporary Clinical Dentistry.2021; 12(3): 213. CrossRef
Modern perspectives of oral squamous cell carcinoma
A.A. Ivina
Arkhiv patologii.2020; 82(3): 55. CrossRef

Review

Provisional Guideline Recommendation for EGFR Gene Mutation Testing in Liquid Samples of Lung Cancer Patients: A Proposal by the Korean Cardiopulmonary Pathology Study Group: Dong Hoon Shin, Hyo Sup Shim, Tae Jung Kim, Heae Surng Park, Yun La Choi, Wan Seop Kim, Lucia Kim, Sun Hee Chang, Joon Seon Song, Hyo jin Kim, Jung Ho Han, Chang Hun Lee, Geon Kook Lee, Se Jin Jang; J Pathol Transl Med. 2019;53(3):153-158. Published online February 28, 2019; DOI: https://doi.org/10.4132/jptm.2019.02.22

7,163 View
246 Download
5 Web of Science
5 Crossref

Abstract PDF

Liquid biopsy for detection of mutation from circulating tumor DNA is a new technology which is attractive in that it is non-invasive. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) is an effective first line drug for advanced non-small cell lung cancer patients who harbor activating EGFR mutation. During the course of treatment, resistance against TKI arises which can be contributed to EGFR T790M mutation in about 50–60% of patients. Third generation TKI may overcome the resistance. In patients who cannot undergo tissue biopsy due to variable reasons, liquid biopsy is an excellent alternative for the detection of EGFR T790M mutation. However, this relatively novel method requires standardization and vigorous quality insurance. Thus, a standard set of guideline recommendations for liquid biopsy for EGFR mutation testing suitable for the Korean medical community is necessary. In this article, we propose a set of provisional guideline recommendations that was discussed and approved by the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists.

Citations

Citations to this article as recorded by

Improving non-small-cell lung cancer survival through molecular characterization: Perspective of a multidisciplinary expert panel
M.G.O. Fernandes, A.S. Vilariça, B. Fernandes, C. Camacho, C. Saraiva, F. Estevinho, H. Novais e Bastos, J.M. Lopes, P. Fidalgo, P. Garrido, S. Alves, S. Silva, T. Sequeira, F. Barata
Pulmonology.2024; 30(1): 4. CrossRef
Exosomes in Lung Cancer: Actors and Heralds of Tumor Development
Amaia Sandúa, Estibaliz Alegre, Álvaro González
Cancers.2021; 13(17): 4330. CrossRef
Molecular biomarker testing for non–small cell lung cancer: consensus statement of the Korean Cardiopulmonary Pathology Study Group
Sunhee Chang, Hyo Sup Shim, Tae Jung Kim, Yoon-La Choi, Wan Seop Kim, Dong Hoon Shin, Lucia Kim, Heae Surng Park, Geon Kook Lee, Chang Hun Lee
Journal of Pathology and Translational Medicine.2021; 55(3): 181. CrossRef
Current status and future perspectives of liquid biopsy in non-small cell lung cancer
Sunhee Chang, Jae Young Hur, Yoon-La Choi, Chang Hun Lee, Wan Seop Kim
Journal of Pathology and Translational Medicine.2020; 54(3): 204. CrossRef
Prevalence of T790M mutation among TKI-therapy resistant Lebanese lung cancer patients based on liquid biopsy analysis: a first report from a major tertiary care center
Hazem Assi, Arafat Tfayli, Nada Assaf, Sarah Abou Daya, Aram H. Bidikian, Dima Kawsarani, Puzant Fermanian, Ghazi Zaatari, Rami Mahfouz
Molecular Biology Reports.2019; 46(4): 3671. CrossRef

Case Studies

Malignant Solitary Fibrous Tumor with Heterologous Rhabdomyosarcomatous Differentiation: A Case Report: Jeong-Hwa Kwon, Joon Seon Song, Hye Won Jung, Jong-Seok Lee, Kyung-Ja Cho; J Pathol Transl Med. 2017;51(2):171-175. Published online February 3, 2017; DOI: https://doi.org/10.4132/jptm.2016.08.29

7,181 View
113 Download
4 Web of Science
4 Crossref

Abstract PDF

Malignant solitary fibrous tumor (MSFT) is a well-described entity, from which heterologous differentiation is extremely rare. We encountered a case of MSFT with rhabdomyosarcomatous differentiation in a 56-year-old man. This patient presented with a large mass in his posterior thigh. He had been treated with chemoradiation for sarcoma involving the cervical spine, right femoral head, and both lungs 6 months earlier. A wide excision was performed. The mass measured 10.6 cm and showed a fish-flesh cut surface with necrotic foci. Microscopically, the tumor showed heterogeneous cellularity with a hemangiopericytic vascular pattern. A hypercellular area showed spindle cells or epithelioid cells with high mitotic activity (63/10 high-power fields) and immunoreactivity for CD34 and CD99. A hypocellular area and a cystic area showed pleomorphic rhabdoid cells with immunoreactivity for desmin and myogenin. This is a report of a rare case of MSFT with rhabdomyosarcomatous differentiation and presents new histologic features of MSFT.

Citations

Citations to this article as recorded by

A Rare Case of Malignant Solitary Fibrous Tumor on the Scalp
Kwang-Ryeol Kim, Ki Hong Kim
Keimyung Medical Journal.2023; 42(2): 107. CrossRef
Malignant solitary fibrous tumor of maxilla presenting as proptosis: A case report
Pravin Kumar, Arpita Jindal, Bhushan Bhalgat, Phanindra Kumar Swain, Raj Govind Sharma
Journal of Cancer Research and Therapeutics.2023; 19(Suppl 2): S991. CrossRef
Recurrent malignant solitary fibrous tumor of the scalp: a case report and literature review
Ahmed Rabie, Abdulkarim Hasan, Yasein Mohammed, Ayman Abdelmaksoud, Ali A. Rabaan
Journal of Pathology and Translational Medicine.2022; 56(2): 103. CrossRef
Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma
Myunghee Kang, Na Rae Kim, Dong Hae Chung, Gie-Taek Yie
Journal of Pathology and Translational Medicine.2019; 53(3): 192. CrossRef

Mammary-Type Myofibroblastoma: A Report of Two Cases: Soyeon An, Joon Seon Song, Soonchan Park, Jung Won Lee, Kyung-Ja Cho; J Pathol Transl Med. 2016;50(5):385-389. Published online June 6, 2016; DOI: https://doi.org/10.4132/jptm.2016.03.26

9,552 View
135 Download
5 Web of Science
8 Crossref

Abstract PDF

Mammary-type myofibroblastoma (MFB) is a rare, benign spindle cell neoplasm occurring along the milkline, with extension from the mid-axilla to the medial groin. It is histologically and immunohistochemically identical to MFB of the breast and is part of a spectrum of lesions that includes spindle cell lipoma and cellular angiofibroma. Recently, we experienced two cases of mammary-type MFB involving male patients aged 30 and 58 years, respectively. The tumors were located in the right scrotal sac and in the right axilla. Wide excisions were performed. Microscopically, the masses were composed of haphazardly arranged, variably sized fascicles of bland spindle cells and were admixed with mature fat tissue. The spindle cells in both cases showed immunopositivity for desmin and CD34 and negativity for smooth muscle actin. Loss of retinoblastoma (RB)/13q14 loci is a characteristic genetic alteration of mammary-type MFB, and we identified loss of RB protein expression by immunohistochemical staining. We emphasize the importance of awareness of this rare neoplasm when a spindle cell neoplasm is accompanied by desmin immunopositivity. The second patient was alive without recurrence for 20 months, and the first patient had not been followed.

Citations

Citations to this article as recorded by

Myofibroblastoma in the Liver: A Case Report and Review of Literature
Mohan Narasimhamurthy, Deepika Savant, Lauren Shreve, Mark A. Rosen, Major Kenneth Lee, Kumarasen Cooper, Emma E. Furth, Paul J. Zhang, Zhaohai Yang
International Journal of Surgical Pathology.2023; 31(8): 1559. CrossRef
Mammary-type myofibroblastoma of the thigh mimicking liposarcoma
Natasha Akhlaq, Bibianna Purgina, Joel Werier, Zaid Jibri
Skeletal Radiology.2022; 51(2): 441. CrossRef
Mammary‐type myofibroblastoma of the perineum: Typical or rare location?
Akihiro Naito, Yuta Takeshima, Sayuri Takahashi
IJU Case Reports.2022; 5(3): 161. CrossRef
Identifying the uncommon solitary fibrous tumour in a rare location – A case report
Shanthi Periasamy, Anita Mani, Graham J. Stewart, Jacob P. Hampton
International Journal of Surgery Case Reports.2022; 94: 107058. CrossRef
Mammary-Type Myofibroblastoma of Perineal Region: A Case Report and Literature Review
晓虹江
Advances in Clinical Medicine.2021; 11(04): 1722. CrossRef
A case of mammary-type myofibroblastoma of the inguinal region
Atsushi Ishihara, Takeo Yasuda, Yukari Sakae, Masayuki Sakae, Tooru Hamada, Hideki Tsukazaki, Takashi Tsukazaki, Masaru Furumoto
International Journal of Surgery Case Reports.2018; 53: 464. CrossRef
Radiologic presentation of a myofibroblastoma of the adult male breast
Evan Rochlis, Pauline Germaine
Radiology Case Reports.2017; 12(3): 439. CrossRef
Imaging features of mammary-type myofibroblastoma of soft tissue: a case series with literature review
Gokhan Kuyumcu, Brian P. Rubin, Carl Winalski
Skeletal Radiology.2017; 46(9): 1283. CrossRef

Original Articles

Accuracy of Core Needle Biopsy Versus Fine Needle Aspiration Cytology for Diagnosing Salivary Gland Tumors: In Hye Song, Joon Seon Song, Chang Ohk Sung, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Jeong Hyun Lee, Jung Hwan Baek, Kyung-Ja Cho; J Pathol Transl Med. 2015;49(2):136-143. Published online March 12, 2015; DOI: https://doi.org/10.4132/jptm.2015.01.03

10,599 View
185 Download
66 Web of Science
63 Crossref

Abstract PDF

Background
Core needle biopsy is a relatively new technique used to diagnose salivary gland lesions, and its role in comparison with fine needle aspiration cytology needs to be refined. Methods: We compared the results of 228 ultrasound-guided core needle biopsy and 371 fine needle aspiration procedures performed on major salivary gland tumors with their postoperative histological diagnoses. Results: Core needle biopsy resulted in significantly higher sensitivity and more accurate tumor subtyping, especially for malignant tumors, than fine needle aspiration. No patient developed major complications after core needle biopsy. Conclusions: We recommend ultrasoundguided core needle biopsy as the primary diagnostic tool for the preoperative evaluation of patients with salivary gland lesions, especially when malignancy is suspected.

Citations

Citations to this article as recorded by

Giant Pleomorphic Adenoma of Submandibular Gland
Harendra Kumar, Qazi Saquib Rizwan, Mayank Gupta, Tarun Kumar
Indian Journal of Otolaryngology and Head & Neck Surgery.2024; 76(1): 1361. CrossRef
CT-guided core needle biopsies of head and neck tumors: a comprehensive monocenter analysis of safety and outcomes
Thomas Joseph Vogl, Heinrich Johannes Ketelsen, Scherwin Mahmoudi, Jan-Erik Scholtz, Vitali Koch, Leon David Grünewald, Peter Wild, Timo Stoever, Simon Bernatz
European Radiology.2024;[Epub] CrossRef
Indications for Submandibulectomy Within a 20-Year Period
Amir Bolooki, Anna Stenzl, Christopher Weusthof, Benedikt Hofauer
Ear, Nose & Throat Journal.2024;[Epub] CrossRef
The Usefulness of Ultrasound-Guided Core Needle Biopsy Compared to Fine Needle Aspiration in Pre-Operative Diagnosis of Cystic-Predominant Parotid Tumors
Youn Jin Cho, Young Rok Jo, Hyun Jun Hong, Hye Ran Lee
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2023; 66(8): 532. CrossRef
The Value of Ultrasound-guided Core Needle Biopsy in Differentiating Benign from Malignant Salivary Gland Lesions
Mohammad Ali Kazemi, Farzaneh Amini, Bita Kargar, Maryam Lotfi, Keyvan Aghazadeh, Hashem Sharifian, Behnaz Moradi, Javid Azadbakht
Indian Journal of Otolaryngology and Head & Neck Surgery.2023; 75(2): 266. CrossRef
Schnellschnittdiagnostik bei Tumoren des Trigonum submandibulare
S. Riemann, A. Knopf
HNO.2023; 71(3): 164. CrossRef
Myoepithelial Carcinoma Ex Pleomorphic Adenoma of the Submandibular Gland: A Case Report
Georgia Syrnioti, Antonia Syrnioti, Alharith Abdullah, Xuehui Lui, Ernesto Mendoza
Cureus.2023;[Epub] CrossRef
Intraductal Carcinoma: The Carcinoma In Situ of the Salivary Gland
Rhema Thomas, Tijjani Umar, Farzad Borumandi
Journal of Craniofacial Surgery.2023; 34(5): e432. CrossRef
Fine-Needle Aspiration Cytology for Parotid Tumors
Masataka Taniuchi, Tetsuya Terada, Ryo Kawata
Life.2022; 12(11): 1897. CrossRef
Utility of the Milan System for Reporting Salivary Gland Cytology, with focus on the incidence and histologic correlates of atypia of undetermined significance (AUS) and salivary gland neoplasm of uncertain malignant potential (SUMP): A 3‐year institution
Christopher M. Cormier, Shweta Agarwal
Cancer Cytopathology.2022; 130(4): 303. CrossRef
Percutaneous CT-Guided Core Needle Biopsies of Head and Neck Masses: Review of 184 Cases at a Single Academic Institution, Common and Special Techniques, Diagnostic Yield, and Safety
R.W. Jordan, D.P. Shlapak, J.C. Benson, F.E. Diehn, D.K. Kim, V.T. Lehman, G.B. Liebo, A.A. Madhavan, J.M. Morris, P.P. Morris, J.T. Verdoorn, C.M. Carr
American Journal of Neuroradiology.2022; 43(1): 117. CrossRef
Nodular fasciitis of the submandibular gland
Ting Suen Wong, Richard Wei Chern Gan, Laszlo Karsai, Bun Yin Winson Wong
BMJ Case Reports.2022; 15(4): e245584. CrossRef
Validation of the Milan system for reporting salivary gland cytopathology: a single institution’s 10-year experience
Christopher Felicelli, Joseph Reznicek, Yevgen Chornenkyy, Lucy Jager, Daniel Johnson
Journal of the American Society of Cytopathology.2022; 11(5): 264. CrossRef
Application of the Milan system for reporting salivary gland cytopathology using cell blocks
Grégoire B. Morand, Raihanah Alsayegh, Alex M. Mlynarek, Marianne Plourde, Tiffany Mach, Marco A. Mascarella, Michael P. Hier, Livia Florianova, Marc P. Pusztaszeri
Virchows Archiv.2022; 481(4): 575. CrossRef
Comparisons among the Ultrasonography Prediction Model, Real-Time and Shear Wave Elastography in the Evaluation of Major Salivary Gland Tumors
Ping-Chia Cheng, Wu-Chia Lo, Chih-Ming Chang, Ming-Hsun Wen, Po-Wen Cheng, Li-Jen Liao
Diagnostics.2022; 12(10): 2488. CrossRef
A Novel Sonographic Scoring Model in the Prediction of Major Salivary Gland Tumors
Wu‐Chia Lo, Chih‐Ming Chang, Chi‐Te Wang, Po‐Wen Cheng, Li‐Jen Liao
The Laryngoscope.2021;[Epub] CrossRef
Assessing the diagnostic accuracy for pleomorphic adenoma and Warthin tumor by employing the Milan System for Reporting Salivary Gland Cytopathology: An international, multi‐institutional study
Derek B. Allison, Alexander P. Smith, Daniel An, James Adam Miller, Khurram Shafique, Sharon Song, Kartik Viswanathan, Elizabeth Eykman, Rema A. Rao, Austin Wiles, Güliz A. Barkan, Ritu Nayar, Guido Fadda, Celeste N. Powers, Esther Diana Rossi, Momin T. S
Cancer Cytopathology.2021; 129(1): 43. CrossRef
Magnetic resonance imaging of salivary gland tumours: Key findings for imaging characterisation
Davide Maraghelli, Michele Pietragalla, Cesare Cordopatri, Cosimo Nardi, Anna Julie Peired, Giandomenico Maggiore, Stefano Colagrande
European Journal of Radiology.2021; 139: 109716. CrossRef
The Milan System, from Its Introduction to Its Current Adoption in the Diagnosis of Salivary Gland Cytology
Esther Diana Rossi
Journal of Molecular Pathology.2021; 2(2): 114. CrossRef
Utility of the Milan system for reporting salivary gland cytopathology during rapid on‐site evaluation (ROSE) of salivary gland aspirates
Aanchal Kakkar, Mukin Kumar, Priyadarsani Subramanian, Arshad Zubair, Rajeev Kumar, Alok Thakar, Deepali Jain, Sandeep R. Mathur, Venkateswaran K. Iyer
Cytopathology.2021; 32(6): 779. CrossRef
Contribution of small tissue biopsy and flow cytometry to preoperative cytological categorization of salivary gland fine needle aspirates according to the Milan System: Single center experience on 287 cases
Tolga Bağlan, Serpil Dizbay Sak, Cevriye Cansız Ersöz, Koray Ceyhan
Diagnostic Cytopathology.2021; 49(4): 509. CrossRef
Is Milan for kids?: The Milan System for Reporting Salivary Gland Cytology in pediatric patients at an academic children's hospital with cytologic‐histologic correlation
Swati P. Satturwar, Maren Y. Fuller, Sara E. Monaco
Cancer Cytopathology.2021; 129(11): 884. CrossRef
Radiographic Interpretation in Oral Medicine and Hospital Dental Practice
Katherine France, Anwar A.A.Y. AlMuzaini, Mel Mupparapu
Dental Clinics of North America.2021; 65(3): 509. CrossRef
Carcinoma ex pleomorphic adenoma of major salivary glands: CT and MR imaging findings
Can Wang, Qiang Yu, Siyi Li, Jingjing Sun, Ling Zhu, Pingzhong Wang
Dentomaxillofacial Radiology.2021; 50(7): 20200485. CrossRef
Salivary gland carcinoma in children and adolescents: The EXPeRT/PARTNER diagnosis and treatment recommendations
Aurore Surun, Dominik T. Schneider, Andrea Ferrari, Teresa Stachowicz‐Stencel, Jelena Rascon, Anna Synakiewicz, Abbas Agaimy, Kata Martinova, Denis Kachanov, Jelena Roganovic, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Frédéric Kolb, Juliette Thariat, Anto
Pediatric Blood & Cancer.2021;[Epub] CrossRef
A Call for Universal Acceptance of the Milan System for Reporting Salivary Gland Cytopathology
Eric Barbarite, Sidharth V. Puram, Adeeb Derakhshan, Esther D. Rossi, William C. Faquin, Mark A. Varvares
The Laryngoscope.2020; 130(1): 80. CrossRef
Preoperative biopsy in parotid malignancies: Variation in use and impact on surgical margins
Liliya Benchetrit, Sina J. Torabi, Elliot Morse, Saral Mehra, Rahmatullah Rahmati, Heather A. Osborn, Benjamin L. Judson
The Laryngoscope.2020; 130(6): 1450. CrossRef
α‐Synuclein Real‐Time Quaking‐Induced Conversion in the Submandibular Glands of Parkinson's Disease Patients
Sireesha Manne, Naveen Kondru, Huajun Jin, Vellareddy Anantharam, Xuemei Huang, Arthi Kanthasamy, Anumantha G. Kanthasamy
Movement Disorders.2020; 35(2): 268. CrossRef
The Accessory Parotid Gland and its Clinical Significance
Mateusz A. Rosa, Dominik P. Łazarz, Jakub R. Pękala, Bendik Skinningsrud, Sigurd S. Lauritzen, Bernard Solewski, Przemysław A. Pękala, Jerzy A. Walocha, Krzysztof A. Tomaszewski
Journal of Craniofacial Surgery.2020; 31(3): 856. CrossRef
Comparison of core needle biopsy and fine‐needle aspiration in diagnosis of ma lignant salivary gland neoplasm: Systematic review and meta‐analysis
Jungheum Cho, Junghoon Kim, Ji Sung Lee, Choong Guen Chee, Youngjune Kim, Sang Il Choi
Head & Neck.2020; 42(10): 3041. CrossRef
The Milan system for reporting salivary gland cytopathology: The clinical impact so far. Considerations from theory to practice
Esther Diana Rossi, William C. Faquin
Cytopathology.2020; 31(3): 181. CrossRef
The role of core needle biopsy in parotid glands lesions with inconclusive fine needle aspiration
Farrokh Heidari, Firouzeh Heidari, Benyamin Rahmaty, Neda Jafari, Kayvan Aghazadeh, Saeed Sohrabpour, Ebrahim Karimi
American Journal of Otolaryngology.2020; 41(6): 102718. CrossRef
Role of Fine Needle Aspiration Cytology in the Diagnosis of Parotid Gland Tumors: Analysis of 193 Cases
Rahim Dhanani, Haissan Iftikhar, Muhammad Sohail Awan, Nida Zahid, Sehrish Nizar Ali Momin
International Archives of Otorhinolaryngology.2020; 24(04): e508. CrossRef
Cytohistological correlation of salivary gland tumours with emphasis on Milan system for reporting: A novel step towards internal quality assurance
Anandraj Vaithy.K, ATM Venkat Raghava, E S Keerthika Sri, K R Umadevi
IP Archives of Cytology and Histopathology Research.2020; 5(4): 283. CrossRef
Diagnosing Recently Defined and Uncommon Salivary Gland Lesions in Limited Cellularity Specimens: Cytomorphology and Ancillary Studies
Esther Diana Rossi, Zubair Baloch, William Faquin, Liron Pantanowitz
AJSP: Reviews and Reports.2020; 25(5): 210. CrossRef
Peripheral T Cell Lymphoma of Parotid Gland: A Diagnostic Challenge
J. G. Aishwarya, Satish Nair, C. N. Patil, Swarna Shivakumar, N. Shrivalli, Ashish Shah
Indian Journal of Otolaryngology and Head & Neck Surgery.2019; 71(S1): 533. CrossRef
Potential utility of core needle biopsy in the diagnosis of IgG4-related dacryoadenitis and sialadenitis
Kenichi Takano, Tsuyoshi Okuni, Keisuke Yamamoto, Ryuta Kamekura, Ryoto Yajima, Motohisa Yamamoto, Hiroki Takahashi, Tetsuo Himi
Modern Rheumatology.2019; 29(2): 393. CrossRef
Retrospective assessment of the effectiveness of the Milan system for reporting salivary gland cytology: A systematic review and meta‐analysis of published literature
Sahar J Farahani, Zubair Baloch
Diagnostic Cytopathology.2019; 47(2): 67. CrossRef
Values of fine‐needle aspiration cytology of parotid gland tumors: A review of 996 cases at a single institution
Manabu Suzuki, Ryo Kawata, Masaaki Higashino, Shuji Nishikawa, Tetsuya Terada, Shin‐Ichi Haginomori, Yoshitaka Kurisu, Yoshinobu Hirose
Head & Neck.2019; 41(2): 358. CrossRef
Positive Surgical Margins in Submandibular Malignancies: Facility and Practice Variation
Liliya Benchetrit, Elliot Morse, Benjamin L. Judson, Saral Mehra
Otolaryngology–Head and Neck Surgery.2019; 161(4): 620. CrossRef
The growth rate and the positive prediction of needle biopsy of clinically diagnosed Warthin’s tumor
Jungirl Seok, Woo-Jin Jeong, Soon-Hyun Ahn, Young Ho Jung
European Archives of Oto-Rhino-Laryngology.2019; 276(7): 2091. CrossRef
The Difference in the Clinical Features Between Carcinoma ex Pleomorphic Adenoma and Pleomorphic Adenoma
Jungirl Seok, Se Jin Hyun, Woo-Jin Jeong, Soon-Hyun Ahn, Hyojin Kim, Young Ho Jung
Ear, Nose & Throat Journal.2019; 98(8): 504. CrossRef
Fine‐needle aspiration cytology and radiological imaging in parotid gland tumours: Our experience in 103 patients
Clare Perkins, Edward Toll, Philip Reece
Clinical Otolaryngology.2019; 44(6): 1124. CrossRef
Ultrasound‐guided core needle biopsy in salivary glands: A meta‐analysis
Hee Joon Kim, Jong Seung Kim
The Laryngoscope.2018; 128(1): 118. CrossRef
Accuracy and effectiveness of ultrasound-guided core-needle biopsy in the diagnosis of focal lesions in the salivary glands
Jose Luis del Cura, Gloria Coronado, Rosa Zabala, Igone Korta, Ignacio López
European Radiology.2018; 28(7): 2934. CrossRef
The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC): an ASC-IAC–sponsored system for reporting salivary gland fine-needle aspiration
Esther Diana Rossi, Zubair Baloch, Marc Pusztaszeri, William C. Faquin
Journal of the American Society of Cytopathology.2018; 7(3): 111. CrossRef
Routine and Advanced Ultrasound of Major Salivary Glands
Kunwar Suryaveer Singh Bhatia, Yuk-Ling Dai
Neuroimaging Clinics of North America.2018; 28(2): 273. CrossRef
The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC): An ASC-IAC-Sponsored System for Reporting Salivary Gland Fine-Needle Aspiration
Esther Diana Rossi, Zubair W. Baloch, Marc Pusztaszeri, William C. Faquin
Acta Cytologica.2018; 62(3): 157. CrossRef
Evaluation and diagnosis of salivary gland neoplasms
Erica Jackson Mayland, Anna M. Pou
Operative Techniques in Otolaryngology-Head and Neck Surgery.2018; 29(3): 129. CrossRef
Feasibility and Safety of Multicenter Tissue and Biofluid Sampling for α-Synuclein in Parkinson’s Disease: The Systemic Synuclein Sampling Study (S4)
Lana M. Chahine, Thomas G. Beach, Nicholas Seedorff, Chelsea Caspell-Garcia, Christopher S. Coffey, Michael Brumm, Charles H. Adler, Geidy E. Serrano, Carly Linder, Sherri Mosovsky, Tatiana Foroud, Holly Riss, Dixie Ecklund, John Seibyl, Danna Jennings, V
Journal of Parkinson's Disease.2018; 8(4): 517. CrossRef
Preoperative diagnostic of parotid gland neoplasms: fine-needle aspiration cytology or core needle biopsy?
Peter Zbären, Asterios Triantafyllou, Kenneth O. Devaney, Vincent Vander Poorten, Henrik Hellquist, Alessandra Rinaldo, Alfio Ferlito
European Archives of Oto-Rhino-Laryngology.2018; 275(11): 2609. CrossRef
A comparison study of the reporting systems for salivary gland fine needle aspirations: Are they really different?
Diana Montezuma, Sule Canberk, Ozlem Aydın, Mehmet Polat Dermirhas, André F. Vieira, Süha Goksel, Ümit İnce, Fernando Schmitt
Diagnostic Cytopathology.2018; 46(10): 859. CrossRef
Pediatric salivary gland carcinomas: Diagnostic and therapeutic management
Céleste Rebours, Vincent Couloigner, Louise Galmiche, Odile Casiraghi, Cécile Badoual, Sabah Boudjemaa, Anthony Chauvin, Monique Elmaleh, Brice Fresneau, Sylvie Fasola, Erea‐Noël Garabédian, Thierry Van Den Abeele, Daniel Orbach
The Laryngoscope.2017; 127(1): 140. CrossRef
Agreement between rapid on‐site evaluation and the final cytological diagnosis of salivary gland specimens
S. Wangsiricharoen, S. Lekawanvijit, S. Rangdaeng
Cytopathology.2017; 28(4): 321. CrossRef
Mesenchymal neoplasms of the head and neck: a cytopathologic analysis on fine needle aspiration
James Lee, Samia Kazmi, Christopher J. VandenBussche, Syed Z. Ali
Journal of the American Society of Cytopathology.2017; 6(3): 105. CrossRef
Clinical Results of Surgical Treatment in Parotid Tumors
Ahmet Kara
Journal of Otolaryngology-ENT Research.2017;[Epub] CrossRef
Parotid gland metastases of distant primary tumours: A diagnostic challenge
Achim M. Franzen, Thomas Günzel, Anja Lieder
Auris Nasus Larynx.2016; 43(2): 187. CrossRef
Modern Radiology in the Management of Head and Neck Cancer
G.J.C. Burkill, R.M. Evans, V.V. Raman, S.E.J. Connor
Clinical Oncology.2016; 28(7): 440. CrossRef
Fine‐needle aspiration and core needle biopsy: An update on 2 common minimally invasive tissue sampling modalities
Paul A. VanderLaan
Cancer Cytopathology.2016; 124(12): 862. CrossRef
Staging and follow-up of high-grade malignant salivary gland tumours: The role of traditional versus functional imaging approaches – A review
Nicole Freling, Flavio Crippa, Roberto Maroldi
Oral Oncology.2016; 60: 157. CrossRef
Biopsy of parotid masses: Review of current techniques
Sananda Haldar, Joseph D Sinnott, Kemal M Tekeli, Samuel S Turner, David C Howlett
World Journal of Radiology.2016; 8(5): 501. CrossRef
Review on the applications of ultrasonography in dentomaxillofacial region
Şehrazat Evirgen
World Journal of Radiology.2016; 8(1): 50. CrossRef
Comprehensive Cytomorphologic Analysis of Pulmonary Adenoid Cystic Carcinoma: Comparison to Small Cell Carcinoma and Non-pulmonary Adenoid Cystic Carcinoma
Seokhwi Kim, Jinah Chu, Hojoong Kim, Joungho Han
Journal of Pathology and Translational Medicine.2015; 49(6): 511. CrossRef

Mdm2 and p53 Expression in Radiation-Induced Sarcomas of the Head and Neck: Comparison with De Novo Sarcomas: Min Jeong Song, Joon Seon Song, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Sung Bae Kim, Sang-wook Lee, Kyung-Ja Cho; Korean J Pathol. 2014;48(5):346-350. Published online October 27, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.5.346

6,820 View
41 Download
3 Crossref

Abstract PDF

Background: The pathogenesis of radiation-induced sarcomas (RISs) is not well known. In RIS, TP53 mutations are frequent, but little is known about Mdm2-p53 interaction, which is a recent therapeutic target of sarcomas. Methods: We studied the immunohistochemical expression of Mdm2 and p53 of 8 RISs. The intervals between radiation therapy and diagnosis of secondary sarcomas ranged from 3 to 17 years. Results: Mdm2 expression was more common in de novo sarcomas than RISs (75% vs 37.5%), and p53 expression was more common in RISs than in de novo cases (75% vs 37.5%). While half of the RISs were Mdm2(–)/p53(+), none of de novo cases showed such combination; while half of de novo sarcomas were Mdm2(+)/p53(–), which are a candidate group of Mdm2 inhibitors, only 1 RIS showed such a combination. Variable immunoprofiles observed in both groups did not correlate with tumor types, except that all of 2 myxofibrosarcomas were Mdm2(+)/p53(+). Conclusions: In conclusion, we speculated that both radiation- induced and de novo sarcomagenesis are not due to a unique genetic mechanism. Mdm2- expression without p53 overexpression in 1 case of RIS decreases the future possibility of applying Mdm2 inhibitors on a subset of these difficult tumors.

Citations

Citations to this article as recorded by

Radiation-Induced Sarcomas of the Head and Neck: A Systematic Review
Andrés Coca-Pelaz, Antti A. Mäkitie, Primož Strojan, June Corry, Avraham Eisbruch, Jonathan J. Beitler, Sandra Nuyts, Robert Smee, Johannes A. Langendijk, William M. Mendenhall, Cesare Piazza, Alessandra Rinaldo, Alfio Ferlito
Advances in Therapy.2021; 38(1): 90. CrossRef
Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma
Christopher S. Hong, Edwin Partovi, James Clune, Anita Huttner, Henry S. Park, Sacit Bulent Omay, Balraj Mittal
Case Reports in Genetics.2021; 2021: 1. CrossRef
Radiation-Induced Sarcoma of the Head and Neck: A Review of the Literature
Lorenzo Giannini, Fabiola Incandela, Marco Fiore, Alessandro Gronchi, Silvia Stacchiotti, Claudia Sangalli, Cesare Piazza
Frontiers in Oncology.2018;[Epub] CrossRef

Finding and Characterizing Mammary Analogue Secretory Carcinoma of the Salivary Gland: Min Jung Jung, Joon Seon Song, Sang Yoon Kim, Soon Yuhl Nam, Jong-Lyel Roh, Seung-Ho Choi, Sung-Bae Kim, Kyung-Ja Cho; Korean J Pathol. 2013;47(1):36-43. Published online February 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.36

12,020 View
93 Download
71 Crossref

Abstract PDF

Background

A new tumor entity of the salivary glands, mammary analogue secretory carcinoma (MASC) with ETV6-NTRK3 translocation, has recently been proposed. MASC was originally diagnosed as adenocarcinoma, not otherwise specified (ANOS), or acinic cell carcinoma (AciCC) by the current World Health Organization classification. We aimed to identify MASC cases by molecular tests, and to characterize their clinical, histological, and immunohistochemical features.

Methods

Thirty cases of MASC candidates were selected after review of 196 salivary gland tumors, and subjected to break-apart ETV6 fluorescence in situ hybridization (FISH), and immunohistochemical study for S100 protein, gross cystic disease fluid protein 15, DOG1, estrogen receptor, and progesterone receptor.

Results

Valid FISH results were obtained in 23 cases, and 13 positive cases were retrieved. MASCs were histologically varied, and the most frequent features observed in 10 cases were low-grade papillary/cystic/glandular patterns, intraluminal secretory materials, ovoid/wrinkled nuclei, and relatively abundant granular eosinophilic cytoplasms, corresponding to papillary-cystic or follicular types of AciCC. All cases showed diffuse immunopositivity for S100 protein. Three cases developed recurrences, but all patients remained alive.

Conclusions

MASC could be a molecularly well-defined salivary gland neoplasm, encompassing some portions of AciCC and ANOS, but its histological spectrum and clinical implication require further investigation.

Citations

Citations to this article as recorded by

Salivary Gland Secretory Carcinoma; Review of 13 Years World‐Wide Experience and Meta‐Analysis
Eyal Yosefof, Tomer Boldes, Daniel Dan, Eyal Robenshtok, Yulia Strenov, Gideon Bachar, Thomas Shpitzer, Aviram Mizrachi
The Laryngoscope.2024; 134(4): 1716. CrossRef
Salivary gland secretory carcinoma presenting as a cervical soft tissue mass: a case report
Parisa Mokhles, Alireza Sadeghipour, Pegah Babaheidarian, Saleh Mohebbi, Zahra Keshtpour Amlashi, Mohammad Hadi Gharib, Mohammad Saeid Ahmadi, Zeinab Khastkhodaei
Journal of Medical Case Reports.2024;[Epub] CrossRef
Mammary analogue secretory carcinoma of the head and neck — Clinicopathological, imaging features and prognosis analysis
Runjia Liu, Chuanzheng Sun, Likang Zhao, Shiyu Zhou, Tao Xie, Ji Zhang, Dengpeng Tang, Lei Li, Yan Xi
Journal of Radiation Research and Applied Sciences.2024; : 100914. CrossRef
Metastatic salivary gland mammary analogue secretory carcinoma (MASC) of parotid gland – A rare case report in the literature review
Aynur Aliyeva, Ziya Karimov, Togay Muderris
Acta Oto-Laryngologica Case Reports.2023; 8(1): 38. CrossRef
Secretory carcinoma of minor salivary glands of buccal mucosa: A case report and review of the literature
Noshad Ali Langah, Abdul Ahad, Shayan Khalid Ghaloo, Muhammad Faisal, Raza Tasawar Hussain, Fareed Akbar Shah
International Journal of Surgery Case Reports.2023; 107: 108357. CrossRef
An Underappreciated Cytomorphological Feature of Secretory Carcinoma of Salivary Gland on Fine Needle Aspiration Biopsy: Case Report with Literature Review
Yinan Hua, Bing Leng, Kenneth E. Youens, Lina Liu
Head and Neck Pathology.2022; 16(2): 567. CrossRef
Clinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report
Kensuke Suzuki, Hiroshi Harada, Masayuki Takeda, Chisato Ohe, Yoshiko Uemura, Akihiko Kawahara, Shunsuke Sawada, Akira Kanda, Bhaswati Sengupta, Hiroshi Iwai
BMC Medical Genomics.2022;[Epub] CrossRef
DOG1 as an Immunohistochemical Marker of Acinic Cell Carcinoma: A Systematic Review and Meta-Analysis
Vincenzo Fiorentino, Patrizia Straccia, Pietro Tralongo, Teresa Musarra, Francesco Pierconti, Maurizio Martini, Guido Fadda, Esther Diana Rossi, Luigi Maria Larocca
International Journal of Molecular Sciences.2022; 23(17): 9711. CrossRef
Secretory carcinoma of the sinonasal cavity and pharynx: A retrospective analysis of four cases and literature review
Changli Yue, Xiaoli Zhao, Donglin Ma, Yingshi Piao
Annals of Diagnostic Pathology.2022; 61: 152052. CrossRef
Secretory carcinoma of the salivary gland: a multi‐institutional clinicopathologic study of 90 cases with emphasis on grading and prognostic factors
Bin Xu, Kartik Viswanathan, Kavita Umrau, Thair A. D. Al‐Ameri, Snjezana Dogan, Kelly Magliocca, Ronald A. Ghossein, Nicole A. Cipriani, Nora Katabi
Histopathology.2022; 81(5): 670. CrossRef
A systematic review of secretory carcinoma of the salivary gland: where are we?
Lísia Daltro Borges Alves, Andreia Cristina de Melo, Thayana Alves Farinha, Luiz Henrique de Lima Araujo, Leandro de Souza Thiago, Fernando Luiz Dias, Héliton Spíndola Antunes, Ana Lucia Amaral Eisenberg, Luiz Claudio Santos Thuler, Daniel Cohen Goldember
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2021; 132(4): e143. CrossRef
A case report of surgical resection of secretory carcinoma in the maxillary and ethmoid sinus
Kurt Willis, Martin Bullock, Matthew H. Rigby
International Journal of Surgery Case Reports.2021; 81: 105750. CrossRef
High‐grade salivary gland carcinoma with the ETV6‐NTRK3 gene fusion: A case report and literature review of secretory carcinoma with high‐grade transformation
Satsuki Asai, Shinji Sumiyoshi, Yosuke Yamada, Ichiro Tateya, Toshitaka Nagao, Sachiko Minamiguchi, Hironori Haga
Pathology International.2021; 71(6): 427. CrossRef
High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance
Alena Skalova, Ilmo Leivo, Henrik Hellquist, Abbas Agaimy, Roderick H.W. Simpson, Göran Stenman, Vincent Vander Poorten, Justin A. Bishop, Alessandro Franchi, Juan C. Hernandez-Prera, David Slouka, Stefan M. Willems, Kerry D. Olsen, Alfio Ferlito
Advances in Anatomic Pathology.2021; 28(3): 107. CrossRef
Radiological features of head and neck mammary analogue secretory carcinoma: 11 new cases with a systematic review of 29 cases reported in 28 publications
Ryo Kurokawa, Mariko Kurokawa, Akira Baba, Yoshiaki Ota, Toshio Moritani, Ashok Srinivasan
Neuroradiology.2021; 63(11): 1901. CrossRef
A case of secretory carcinoma of the salivary glands in the lower lip
Reiko OHARA, Haruki SATO, Kensuke NAGANAWA, Taihei HAYAKAWA, Tatsuya KATAOKA, Ichiro OH-IWA
Japanese Journal of Oral and Maxillofacial Surgery.2021; 67(2): 83. CrossRef
Undifferentiated and dedifferentiated head and neck carcinomas
Alessandro Franchi, Alena Skalova
Seminars in Diagnostic Pathology.2021; 38(6): 127. CrossRef
Cytopathological Findings of Secretory Carcinoma of the Salivary Gland and the Diagnostic Utility of Giemsa Staining
Yuria Egusa, Midori Filiz Nishimura, Satoko Baba, Kengo Takeuchi, Takuma Makino, Tomoyasu Tachibana, Asami Nishikori, Azusa Fujita, Hiroyuki Yanai, Yasuharu Sato
Diagnostics.2021; 11(12): 2284. CrossRef
Diagnosis and treatment of secretory carcinoma arising from the oral minor salivary gland
Masaru Ogawa, Satoshi Yokoo, Takahiro Yamaguchi, Keisuke Suzuki, Mai Seki-Soda, Takahiro Shimizu, Jun Kurihara, Takaya Makiguchi
Medicine.2021; 100(51): e28390. CrossRef
A biphasic sessile mass of the buccal mucosa
Tiffany M. Peters, James A. Phero, Brent A. Golden, Alice E. Curran
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2020; 130(6): 612. CrossRef
Don't stop the champions of research now: a brief history of head and neck pathology developments
Lester D.R. Thompson, James S. Lewis, Alena Skálová, Justin A. Bishop
Human Pathology.2020; 95: 1. CrossRef
High Grade Transformation in Mucoepidermoid Carcinoma of the Minor Salivary Gland with Polyploidy of the Rearranged MAML2 Gene
Hyun Lee, Jong-Lyel Roh, Young-Jun Choi, Jene Choi, Kyung-Ja Cho
Head and Neck Pathology.2020; 14(3): 822. CrossRef
Pan‐Trk immunohistochemistry is a sensitive and specific ancillary tool for diagnosing secretory carcinoma of the salivary gland and detecting ETV6–NTRK3 fusion
Bin Xu, Mohamed R Haroon Al Rasheed, Cristina R Antonescu, Deepu Alex, Denise Frosina, Ronald Ghossein, Achim A Jungbluth, Nora Katabi
Histopathology.2020; 76(3): 375. CrossRef
Characterization of novel genetic alterations in salivary gland secretory carcinoma
Kiyong Na, Juan C. Hernandez-Prera, Jae-Yol Lim, Ha Young Woo, Sun Och Yoon
Modern Pathology.2020; 33(4): 541. CrossRef
Mammary analogue secretory carcinoma: An Indian experience of a novel entity
Zeba Nisar, JaydeepN Pol, RakhiV Jagdale, MadhuraD Phadke, GirishA Kadkol
Indian Journal of Pathology and Microbiology.2020; 63(5): 134. CrossRef
Secretory Carcinoma of Salivary Gland with High-Grade Histology Arising in Hard Palate: A Case Report
Kiyofumi Takabatake, Keisuke Nakano, Hotaka Kawai, Saori Yoshida, Haruka Omori, May Wathone Oo, Shan Qiusheng, Kenichiro Uchida, Katsuaki Mishima, Hitoshi Nagatsuka
Reports — Medical Cases, Images, and Videos.2020; 3(2): 6. CrossRef
Secretory carcinoma of the salivary gland (mammary analogue secretory carcinoma) in children
I. V. Sidorov, I. S. Kletskaya, D. M. Konovalov
Arkhiv patologii.2020; 82(2): 43. CrossRef
Secretory carcinoma of the major salivary gland: Provincial population‐based analysis of clinical behavior and outcomes
Gareth Ayre, Martin Hyrcza, Jonn Wu, Eric Berthelet, Alena Skálová, Tom Thomson
Head & Neck.2019; 41(5): 1227. CrossRef
Higher Ki67 Index, Nodal Involvement, and Invasive Growth Were High Risk Factors for Worse Prognosis in Conventional Mammary Analogue Secretory Carcinoma
Jingjing Sun, Lizhen Wang, Zhen Tian, Yuhua Hu, Ronghui Xia, Jiang Li
Journal of Oral and Maxillofacial Surgery.2019; 77(6): 1187. CrossRef
Mammary analogue secretory carcinoma of salivary gland diagnosed on submandibular gland cytology: A case report and review of the literature
Ethar Al‐Husseinawi, Soheila Hamidpour, Evanthia Omoscharka
Cytopathology.2019; 30(3): 318. CrossRef
Secretory Carcinoma of Minor Salivary Gland in Buccal Mucosa: A Case Report and Review of the Literature
Durga Paudel, Michiko Nishimura, Bhoj Raj Adhikari, Daichi Hiraki, Aya Onishi, Tetsuro Morikawa, Puja Neopane, Sarita Giri, Koki Yoshida, Jun Sato, Masayuki Ono, Yoshitaka Kamino, Hiroki Nagayasu, Yoshihiro Abiko
Case Reports in Pathology.2019; 2019: 1. CrossRef
Estrogen Receptor, Progesterone Receptor, and HER-2 Expression in Recurrent Pleomorphic Adenoma
Ana Amélia de Souza, Albina Altemani, Ney Soares de Araujo, Lucas Novaes Texeira, Vera Cavalcanti de Araújo, Andresa Borges Soares
Clinical Pathology.2019; 12: 2632010X1987338. CrossRef
Sinonasal Secretory Carcinoma of Salivary Gland with High Grade Transformation: A Case Report of this Under-Recognized Diagnostic Entity with Prognostic and Therapeutic Implications
Bin Xu, Ruth Aryeequaye, Lu Wang, Nora Katabi
Head and Neck Pathology.2018; 12(2): 274. CrossRef
Primary mammary analogue secretory carcinoma of the lung: a case report
Tao Huang, Jonathan B. McHugh, Gerald J. Berry, Jeffrey L. Myers
Human Pathology.2018; 74: 109. CrossRef
Salivary Secretory Carcinoma With a Novel ETV6-MET Fusion
Lisa M. Rooper, Theodoros Karantanos, Yi Ning, Justin A. Bishop, Sarah W. Gordon, Hyunseok Kang
American Journal of Surgical Pathology.2018; 42(8): 1121. CrossRef
Secretory carcinoma: The eastern Canadian experience and literature review
David Forner, Martin Bullock, Daniel Manders, Timothy Wallace, Christopher J. Chin, Liane B. Johnson, Matthew H. Rigby, Jonathan R. Trites, Mark S. Taylor, Robert D. Hart
Journal of Otolaryngology - Head & Neck Surgery.2018;[Epub] CrossRef
Newly described salivary gland tumors
Alena Skalova, Michal Michal, Roderick HW Simpson
Modern Pathology.2017; 30: S27. CrossRef
Diagnóstico, tratamiento y seguimiento de un tumor de reciente descripción: el carcinoma análogo secretor de mama (MASC) de glándula salival. A propósito de 2 nuevos casos
Marina Alexandra Gavín-Clavero, M. Victoria Simón-Sanz, Ana M. López-López, Alberto Valero-Torres, Esther Saura-Fillat
Revista Española de Cirugía Oral y Maxilofacial.2017; 39(4): 221. CrossRef
Systematic review of mammary analog secretory carcinoma of salivary glands at 7 years after description
Bacem A. Khalele
Head & Neck.2017; 39(6): 1243. CrossRef
Salivary Gland Secretory Carcinoma With High-Grade Transformation, CDKN2A/B Loss, Distant Metastasis, and Lack of Sustained Response to Crizotinib
Nicole A. Cipriani, Elizabeth A. Blair, Joshua Finkle, Jennifer L. Kraninger, Christopher M. Straus, Victoria M. Villaflor, Daniel Thomas Ginat
International Journal of Surgical Pathology.2017; 25(7): 613. CrossRef
A systematic review including an additional pediatric case report: Pediatric cases of mammary analogue secretory carcinoma
Amanda L. Ngouajio, Sarah M. Drejet, D. Ryan Phillips, Don-John Summerlin, John P. Dahl
International Journal of Pediatric Otorhinolaryngology.2017; 100: 187. CrossRef
Newly Described Entities in Salivary Gland Pathology
Alena Skálová, Douglas R. Gnepp, James S. Lewis, Jennifer L. Hunt, Justin A. Bishop, Henrik Hellquist, Alessandra Rinaldo, Vincent Vander Poorten, Alfio Ferlito
American Journal of Surgical Pathology.2017; 41(8): e33. CrossRef
Mammary Analogue Secretory Carcinoma of Salivary Glands: Diagnostic Pitfall with Distinct Immunohistochemical Profile and Molecular Features
Oliver Bissinger, Carolin Götz, Andreas Kolk, Henning A. Bier, Abbas Agaimy, Henning Frenzel, Sven Perner, Julika Ribbat-Idel, Klaus Dietrich Wolff, Wilko Weichert, Caroline Mogler
Rare Tumors.2017; 9(3): 89. CrossRef
Mammary Analogue Secretory Carcinoma of Salivary Gland. A Case Report Emphasizing its Diagnostic Histological, Immunohistochemistry and Molecular Findings
Monalisa Hui, Shantveer G Uppin, Vamshi Krishna Thamtam, Abhiram Kalle
International Journal of Head and Neck Surgery.2017; 8(4): 160. CrossRef
A case of mammary analog secretory carcinoma of the lower lip
Takako Aizawa, Taro Okui, Ken Kitagawa, Yoshikazu Kobayashi, Koji Satoh, Hideki Mizutani
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2016; 28(3): 277. CrossRef
Mammary analogue secretory carcinoma of parotid: Is preoperative cytological diagnosis possible?
Nikita Oza, Kintan Sanghvi, Tanuja Shet, Asawari Patil, Santosh Menon, Mukta Ramadwar, Shubhada Kane
Diagnostic Cytopathology.2016; 44(6): 519. CrossRef
Lysozyme Expression Can be Useful to Distinguish Mammary Analog Secretory Carcinoma from Acinic Cell Carcinoma of Salivary Glands
Fernanda Viviane Mariano, Camila Andrea Concha Gómez, Juliana de Souza do Nascimento, Harim Tavares dos Santos, Erika Said Egal, Victor Angelo Martins Montalli, Pablo Agustin Vargas, Oslei Paes de Almeida, Albina Altemani
Head and Neck Pathology.2016; 10(4): 429. CrossRef
Cytogenetic and immunohistochemical characterization of mammary analogue secretory carcinoma of salivary glands
Syed A. Khurram, Jemel Sultan-Khan, Neil Atkey, Paul M. Speight
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2016; 122(6): 731. CrossRef
The role of DOG1 immunohistochemistry in dermatopathology
Keisuke Goto
Journal of Cutaneous Pathology.2016; 43(11): 974. CrossRef
Extended immunologic and genetic lineage of mammary analogue secretory carcinoma of salivary glands
Hao Ni, Xue-ping Zhang, Xiao-tong Wang, Qiu-yuan Xia, Jing-huan Lv, Xuan Wang, Shan-shan Shi, Rui Li, Xiao-jun Zhou, Qiu Rao
Human Pathology.2016; 58: 97. CrossRef
A New Hitherto Unreported Histopathologic Manifestation of Mammary Analogue Secretory Carcinoma: “Masked MASC” Associated With Low-grade Mucinous Adenocarcinoma and Low-grade In Situ Carcinoma Components
Fredrik Petersson, Michael Michal, Dmitry V. Kazakov, Petr Grossmann, Michal Michal
Applied Immunohistochemistry & Molecular Morphology.2016; 24(9): e80. CrossRef
Papillary-cystic pattern is characteristic in mammary analogue secretory carcinomas but is rarely observed in acinic cell carcinomas of the salivary gland
Min-Shu Hsieh, Yueh-Hung Chou, Shin-Joe Yeh, Yih-Leong Chang
Virchows Archiv.2015; 467(2): 145. CrossRef
Mammary analog secretory carcinoma, low-grade salivary duct carcinoma, and mimickers: a comparative study
Todd M Stevens, Andra O Kovalovsky, Claudia Velosa, Qiuying Shi, Qian Dai, Randall P Owen, Walter C Bell, Shi Wei, Pamela A Althof, Jennifer N Sanmann, Larissa Sweeny, William R Carroll, Gene P Siegal, Martin J Bullock, Margaret Brandwein-Gensler
Modern Pathology.2015; 28(8): 1084. CrossRef
Aspiration cytology of mammary analogue secretory carcinoma of the salivary gland
Min Jung Jung, Sang Yoon Kim, Soon Yuhl Nam, Jong‐Lyel Roh, Seung‐Ho Choi, Jeong Hyun Lee, Jung Hwan Baek, Kyung‐Ja Cho
Diagnostic Cytopathology.2015; 43(4): 287. CrossRef
A Unique Case of a Cutaneous Lesion Resembling Mammary Analog Secretory Carcinoma
Jennifer Albus, Jacqueline Batanian, Bruce M. Wenig, Claudia I. Vidal
The American Journal of Dermatopathology.2015; 37(4): e41. CrossRef
Mammary analogue secretory carcinoma of salivary glands: a new entity associated with ETV6 gene rearrangement
Hanna Majewska, Alena Skálová, Dominik Stodulski, Adéla Klimková, Petr Steiner, Czesław Stankiewicz, Wojciech Biernat
Virchows Archiv.2015; 466(3): 245. CrossRef
A comparative immunohistochemistry study of diagnostic tools in salivary gland tumors: usefulness of mammaglobin, gross cystic disease fluid protein 15, and p63 cytoplasmic staining for the diagnosis of mammary analog secretory carcinoma?
Fabrice Projetti, Magali Lacroix‐Triki, Elie Serrano, Sebastien Vergez, Béatrice Herbault Barres, Julie Meilleroux, Marie‐Bernadette Delisle, Emmanuelle Uro‐Coste
Journal of Oral Pathology & Medicine.2015; 44(4): 244. CrossRef
Mammary Analogue Secretory Carcinoma of Salivary Glands
Yohei Ito, Kenichiro Ishibashi, Ayako Masaki, Kana Fujii, Yukio Fujiyoshi, Hideo Hattori, Daisuke Kawakita, Manabu Matsumoto, Satoru Miyabe, Kazuo Shimozato, Toshitaka Nagao, Hiroshi Inagaki
American Journal of Surgical Pathology.2015; 39(5): 602. CrossRef
Cytopathological features of mammary analogue secretory carcinoma—Review of literature
Maiko Takeda, Takahiko Kasai, Kohei Morita, Mao Takeuchi, Takeshi Nishikawa, Akinori Yamashita, Shinji Mikami, Hiroshi Hosoi, Chiho Ohbayashi
Diagnostic Cytopathology.2015; 43(2): 131. CrossRef
Mammary Analog Secretory Carcinoma of Salivary Glands
Justin A. Bishop
Pathology Case Reviews.2015; 20(1): 7. CrossRef
Diagnostic utility of phosphorylated signal transducer and activator of transcription 5 immunostaining in the diagnosis of mammary analogue secretory carcinoma of the salivary gland: A comparative study of salivary gland cancers
Akihiko Kawahara, Tomoki Taira, Hideyuki Abe, Yorihiko Takase, Takashi Kurita, Eiji Sadashima, Satoshi Hattori, Ichio Imamura, Shinji Matsumoto, Hitomi Fujisaki, Kazunobu Sueyoshi, Jun Akiba, Masayoshi Kage
Cancer Cytopathology.2015; 123(10): 603. CrossRef
A Case of Mammary Analogue Secretory Carcinoma Arising from Parotid Gland
Hee Tae Kim, Cha Hee Lee, Han Su Kim, Hae Sang Park
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2015; 58(8): 563. CrossRef
WITHDRAWN: A biphasic sessile mass of the buccal mucosa
Tiffany M. Peters, Jose P. Zevallos, Brent A. Golden, Alice E. Curran
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2015;[Epub] CrossRef
Mammary analogue secretory carcinoma: an evaluation of its clinicopathological and genetic characteristics
Peter P. Luk, Christina I. Selinger, Timothy J. Eviston, Trina Lum, Bing Yu, Sandra A. O’Toole, Jonathan R. Clark, Ruta Gupta
Pathology.2015; 47(7): 659. CrossRef
A case of mammary analogue secretory carcinoma arising in the submandibular region
Kotaro ISHII, Koji NAKAMATSU, Koji SATO, Chikashi MINEMURA, Wataru KUMAMARU, Hiroyo YOSHIKAWA
Japanese Journal of Oral and Maxillofacial Surgery.2015; 61(11): 564. CrossRef
DOG1, p63, and S100 protein: a novel immunohistochemical panel in the differential diagnosis of oncocytic salivary gland neoplasms in fine-needle aspiration cell blocks
Alessandra C. Schmitt, Ryan McCormick, Cynthia Cohen, Momin T. Siddiqui
Journal of the American Society of Cytopathology.2014; 3(6): 303. CrossRef
Salivary Gland Tumor “Wishes” to Add to the Next WHO Tumor Classification: Sclerosing Polycystic Adenosis, Mammary Analogue Secretory Carcinoma, Cribriform Adenocarcinoma of the Tongue and Other Sites, and Mucinous Variant of Myoepithelioma
Douglas R. Gnepp
Head and Neck Pathology.2014; 8(1): 42. CrossRef
Hepatoid differentiation in renal cell carcinoma: a rare histologic pattern with clinical significance
Jungweon Shim, Heounjeong Go, Young-Suk Lim, Kyung Chul Moon, Jae Y. Ro, Yong Mee Cho
Annals of Diagnostic Pathology.2014; 18(6): 363. CrossRef
Mammary analogue secretory carcinoma: Update on a new diagnosis of salivary gland malignancy
Roshan Sethi, Elliott Kozin, Aaron Remenschneider, Josh Meier, Paul VanderLaan, William Faquin, Daniel Deschler, Robert Frankenthaler
The Laryngoscope.2014; 124(1): 188. CrossRef
Mammary analog secretory carcinoma of salivary gland in a 5 year old: Case report
Matthew Keisling, Michael Bianchi, Judy Mae Pascasio
International Journal of Pediatric Otorhinolaryngology Extra.2014; 9(4): 163. CrossRef
Fine-Needle Aspiration Cytology of Mammary Analog Secretory Carcinoma Masquerading as Low-Grade Mucoepidermoid Carcinoma: Case Report with a Review of the Literature
Jaya Bajaj, Cecilia Gimenez, Farah Slim, Mohamed Aziz, Kasturi Das
Acta Cytologica.2014; 58(5): 501. CrossRef

Case Reports

Cellular Pseudosarcomatous Fibroepithelial Stromal Polyp of the Vagina during Pregnancy: A Lesion That Is Overdiagnosed as a Malignant Tumor: Joon Seon Song, Dong Eun Song, Kyu-Rae Kim, Jae Y. Ro; Korean J Pathol. 2012;46(5):494-498. Published online October 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.5.494

8,902 View
76 Download
9 Crossref

Abstract PDF

Fibroepithelial stromal polyp (FSP) is a benign lesion that can occur at various sites, including the lower female genital tract. In rare cases, however, it may exhibit hypercellularity, bizarre cytomorphological features, and atypical mitoses resulting in an overdiagnosis as a malignant tumor despite its benign clinical course. Recently, we experienced one case of a 30-year-old pregnant woman with cellular pseudosarcomatous FSP that was initially diagnosed as a malignant fibrous histiocytoma at a primary clinic. In addition to describing the rare features of this case, we wish to increase awareness about this benign lesion which will be essential for avoiding unnecessary radical surgery or chemoradiation treatment.

Citations

Citations to this article as recorded by

Fibroepithelial Polyp of the Vagina With Torsion: A Difficult Diagnosis Based on Clinical and Morphological Findings of the Vaginal Lesion
Efthymia Thanasa, Anna Thanasa, Gerasimos Kontogeorgis, Ektoras-Evangelos Gerokostas, Ioannis-Rafail Antoniou, Athanasios Chasiotis, Emmanouil M Xydias, Apostolos C Ziogas, Evangelos Kamaretsos, Ioannis Thanasas
Cureus.2024;[Epub] CrossRef
Recurrent fibroepithelial vaginal polyp in a 2-year-old girl: a case report and review of the literature
Mohammad Hakam Shehadeh, Ahmad M. Abualrub, Waleed M. Malhes, Amar Msarweh, Wael Amro
Annals of Medicine & Surgery.2024; 86(4): 2335. CrossRef
A vaginal fibroepithelial stromal polyp: a case report with magnetic resonance images
Naoko Ogura, Mieko Inagaki, Ritsuko Yasuda, Shigeki Yoshida, Tetsuo Maeda
BJR|case reports.2022;[Epub] CrossRef
Fast-growing fibroepithelial stromal vaginal polyp
Ana Marta Pinto, Maria Boia Martins, Isabel Ferreira, Clara Moreira
BMJ Case Reports.2022; 15(6): e250076. CrossRef
Giant hypopharyngeal fibroepithelial polyp: A case report and literature review
Muhammad Nour Alabdullah, Nagham Halaweek, Yasser Al Ghabra, Mohammad Hamdi, Mhd Ayham Abo Trab, Faysal Hajjar
Ear, Nose & Throat Journal.2022; : 014556132211467. CrossRef
Mesenchymal lesions of the vulva
David B. Chapel, Nicole A. Cipriani, Jennifer A. Bennett
Seminars in Diagnostic Pathology.2021; 38(1): 85. CrossRef
Giant Fibroepithelial Stromal Polyp of the Vulva: Diffusion-Weighted and Conventional Magnetic Resonance Imaging Features and Pathologic Correlation
Joonghyun Yoo, Bo-Kyung Je, Suk Keu Yeom, Ye Sul Park, Kyung-Jin Min, Joo Han Lee
Journal of Pediatric and Adolescent Gynecology.2019; 32(1): 93. CrossRef
Cellular Pseudosarcomatous Fibroepithelial Stromal Polyp of the Cervix: A Lesion Mimicking as Sarcoma
Ruquiya Afrose
Advances in Cytology & Pathology.2018;[Epub] CrossRef
Pseudosarcomatous Vaginal Polyp
Alexis Heller, Adanna Ukazu, Qing Wang
International Journal of Surgical Pathology.2017; 25(1): 54. CrossRef

Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytology Diagnosis of Solid Pseudopapillary Neoplasm: Three Case Reports with Review of Literature: Joon Seon Song, Chong Woo Yoo, Youngmee Kwon, Eun Kyung Hong; Korean J Pathol. 2012;46(4):399-406. Published online August 23, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.4.399

7,698 View
51 Download
14 Crossref

Abstract PDF

Solid pseudopapillary neoplasm of the pancreas (SPN) is relatively rare and it occurs almost exclusively in women. We recently experienced three cases of SPN diagnosed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). These three cases were two male and one female patient whose age was 29, 37, and 44 years old. Radiological diagnosis was pancreatic endocrine tumor (PEN) showing solid with a heterogenous echogenicity. EUS-FNA cytology specimens consisted of single cells and aggregates of uniform cells, forming microadenoid structures, branching, papillary clusters with delicate fibrovascular cores. In conclusion, a single diagnosis of SPN based on clinical and radiological findings would be risky because there is a possibility of it being misdiagnosed as PEN or other malignancies. An EUS-FNA is therefore essential for establishing the diagnosis. In addition, the pathologists should recognize the characteristic cytologic findings with immunoprofiles of SPN to prevent misdiagnosis of SPN.

Citations

Citations to this article as recorded by

Laparoscopic parenchyma-sparing resections for solid pseudopapillary tumors located in the head of pancreas
Zhengdong Zou, Lu Feng, Bing Peng, Jianhua Liu, Yunqiang Cai
BMC Surgery.2023;[Epub] CrossRef
Solid pancreatic masses in children: A review of current evidence and clinical challenges
Kelli N. Patterson, Andrew T. Trout, Archana Shenoy, Maisam Abu-El-Haija, Jaimie D. Nathan
Frontiers in Pediatrics.2022;[Epub] CrossRef
Pancreatic solid pseudopapillary neoplasm in male patients: systematic review with three new cases
Anna Caterina Milanetto, Anna-Lea Gais Zürcher, Lorenzo Macchi, Alina David, Claudio Pasquali
Updates in Surgery.2021; 73(4): 1285. CrossRef
Silencing c-Myc Enhances the Antitumor Activity of Bufalin by Suppressing the HIF-1α/SDF-1/CXCR4 Pathway in Pancreatic Cancer Cells
Xia Liu, Yayun Zhou, Jiamin Peng, Bei Xie, Qiyang Shou, Jianchao Wang
Frontiers in Pharmacology.2020;[Epub] CrossRef
Simultaneous colorectal and parenchymal-sparing liver resection for advanced colorectal carcinoma with synchronous liver metastases: Between conventional and mini-invasive approaches
Emilio De Raffele, Mariateresa Mirarchi, Dajana Cuicchi, Ferdinando Lecce, Riccardo Casadei, Claudio Ricci, Saverio Selva, Francesco Minni
World Journal of Gastroenterology.2020; 26(42): 6529. CrossRef
Solid pseudopapillary neoplasm of the pancreas showing marked distal atrophy: A case report
Masanori Tsujie, Tomoko Wakasa, Shigeto Mizuno, Hajime Ishikawa, Hironobu Manabe, Taichi Koyama, Kotaro Kitani, Shumpei Satoi, Keisuke Inoue, Shuichi Fukuda, Toshihiko Kawasaki, Masao Yukawa, Yoshio Ohta, Masatoshi Inoue
International Journal of Surgery Case Reports.2019; 55: 136. CrossRef
Solid pseudopapillary neoplasm of the pancreas in pediatric patients: A case report and institutional case series
Justin B. Mahida, Rajan K. Thakkar, Jon Walker, Rulong Shen, Brian D. Kenney, Vinay Prasad, Jennifer H. Aldrink
Journal of Pediatric Surgery Case Reports.2015; 3(4): 149. CrossRef
Onsite cytopathology evaluation and ancillary studies beneficial in EUS‐FNA of pancreatic, mediastinal, intra‐abdominal, and submucosal lesions
Shafqat Mehmood, Amna Jahan, Asif Loya, Muhammed Aasim Yusuf
Diagnostic Cytopathology.2015; 43(4): 278. CrossRef
Multicentric solid pseudopapillary neoplasms of the pancreas diagnosed by endoscopic ultrasound-guided fine needle aspiration: a case report
Megumi Yamaguchi, Toshikatsu Fukuda, Masahiro Nakahara, Mio Amano, Daisuke Takei, Masumi Kawashima, Yusuke Sumi, Hironobu Amano, Shuji Yonehara, Keiji Hanada, Toshio Noriyuki
Surgical Case Reports.2015;[Epub] CrossRef
A solid pseudopapillary neoplasm without cysts that occurred in a patient diagnosed by endoscopic ultrasound-guided fine-needle aspiration: a case report
Masakuni Fujii, Masao Yoshioka, Takefumi Niguma, Hiroaki Saito, Toru Kojima, Soichiro Nose, Junji Shiode
Journal of Medical Case Reports.2014;[Epub] CrossRef
Surgical Management and Long-Term Follow-Up of Solid Pseudopapillary Tumor of Pancreas: A Large Series from a Single Institution
Yunqiang Cai, Xun Ran, Siming Xie, Xin Wang, Bing Peng, Gang Mai, Xubao Liu
Journal of Gastrointestinal Surgery.2014; 18(5): 935. CrossRef
A case of solid-pseudopapillary neoplasm in a middle-aged male preoperatively diagnosed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA)
Shin KATO, Takuya HONBU, Moriya ZAKIMI, Kenji CHINEN, Tomiaki KUBOTA, Masayuki ARASHIRO, Kaoru KIKUCHI, Takahiro MURAKAMI, Fumihito KUNISHIMA
Suizo.2014; 29(2): 263. CrossRef
Endoscopic ultrasound-guided fine needle aspiration improves the pre-operative diagnostic yield of solid-pseudopapillary neoplasm of the pancreas: an international multicenter case series (with video)
Joanna K. Law, Alina Stoita, Wallia Weaver, Ferga C. Gleeson, Andrew M. Dries, Amanda Blackford, Vandhana Kiswani, Eun Ji Shin, Mouen A. Khashab, Marcia Irene Canto, Vikesh K. Singh, Anne Marie Lennon
Surgical Endoscopy.2014; 28(9): 2592. CrossRef
Multiple Diagnostic Imaging of a Patient with Solid Pseudopapillary Tumour of the Pancreas: EUS, CT and FDG PET/CT
Ari Chong, Jung-Min Ha, Seong Young Kwon
Nuclear Medicine and Molecular Imaging.2014; 48(1): 82. CrossRef

Original Article

Outcome of "Atypical Squamous Cells" in Cervical Cytology: Follow-up Assessment by Loop Electrical Excision Procedure: Joon Seon Song, Ilseon Hwang, Gyungyub Gong; Korean J Pathol. 2012;46(4):359-364. Published online August 23, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.4.359

6,560 View
59 Download
1 Crossref

Abstract PDF

Background

We have retrospectively assessed the incidence and outcome of women diagnosed during a hospital-based cytology screening program with "atypical squamous cells (ASC)" and followed-up with loop electrical excision procedure (LEEP).

Methods

We analyzed 173,947 cases of cervical smears' follow-up cytology and histology findings. Previous or archival cytology with LEEP results were retrieved for 390 women with ASC of undetermined significance (ASC-US) and 112 with ASC, cannot exclude high-grade squamous intraepithelial lesion (ASC-H).

Results

On the follow-up cytology, of the 390 women initially diagnosed with ASC-US, 130 (33.3%) had no follow-up records of smears before LEEP; smears of 18 (4.6%) were negative for cytologic abnormalities, 193 (49.5%) were ASC-US, 24 (6.2%) were ASC-H, 111 (28.5%) were low grade squamous intraepithelial lesion (SIL), and 44 (11.4%) were high grade SIL. LEEP findings in these 390 women showed that 183 (46.9%) were negative, 73 (18.7%) were graded as cervical intraepithelial neoplasia (CIN) 1, 25 (6.4%) as CIN 2, 102 (26.2%) as CIN 3, and 7 (1.8%) had carcinoma. LEEP was performed in 112 women initially diagnosed with ASC-H; 36 (32.1%) were negative, 4 (3.6%) were graded as CIN 1, 7 (6.3%) as CIN 2, 60 (53.6%) as CIN 3, and 5 (4.5%) with carcinoma.

Conclusions

Patients with ASC-H smears were at increased risk of SIL or carcnoma compared with patients with ASC-US. Careful follow-up is required in ASC patients.

Citations

Citations to this article as recorded by

Incisal margin condition after LEEP for cervical intraepithelial neoplasia patients and prognosis
Hong Chen, Xiufeang Liu, Lina Xu
Experimental and Therapeutic Medicine.2016; 12(2): 1019. CrossRef

First
Prev
Page of 2
Next
Last

Search